The role of the extracellular vesicles in cardiovascular regeneration
Extracellular vesicles (EVs) are released by a variety of cell types and are today known as critical mediators of intercellular communication during…
Cardiac progenitor cells in cardiac regeneration
The limited regeneration capacity of the adult mammalian heart increases the risk of heart failure that develops after cardiac damage. The expectation from the progenitor/stem cell-based therapy is that differentiation of the transplanted cells into specialized cardiac cells and/or trigger the cellular and molecular mechanisms governing repair via paracrine effect. But insufficient cell engraftment, late cardiac functional recovery are major concerns in this treatment method.
Stem/progenitor cells also contribute to cardiac repair releasing extracellular vesicles which can lead to angiogenesis and tissue repair. In recent years there has been a huge interest on the using of stem/progenitor cell-derived extracellular vesicles due to their potential therapeutic applications.
We aim to increase transplantation effieciency of both cardiac progenitor cells (CPCs) and cardiac progenitor cell-derived extracellular vesicles via different approaches.
